Treatment for HoFH
Homozygous familial hypercholesterolemia (HoFH) is the rare and most severe form of FH, characterized by LDL cholesterol levels over 400 mg/dL and a family history of high cholesterol and/or early heart disease, usually on both sides of the family. Treatment for HoFH should begin as soon as possible, regardless of age. Anyone with HoFH, or suspecting HoFH, should be seen by a specialist.
A great deal of progress in HoFH treatment has been made in recent years. There are multiple effective treatments for HoFH available today. A combination of treatments is usually required to lower LDL cholesterol to recommended levels.
Tools and Resources
The Family Heart Foundation has created these resources for understanding treatment options for homozygous familial hypercholesterolemia and lowering high cholesterol:
Cholesterol Lowering Medications for Familial Hypercholesterolemia
Note: Liver Transplant for HoFH In very rare cases, a liver transplant is recommended to replace a person’s liver with a new liver that does not have any FH causing genes. It generally is reserved for very young patients with Homozygous Familial Hypercholesterolemia and advanced atherosclerosis for whom other treatment options have not been sufficient.
Lifestyle Changes to Manage Familial Hypercholesterolemia
Lifestyle changes enhance medication efficacy. Heart-healthy decisions benefit you and your entire family if they join you in your efforts. Don’t be afraid to seek advice from a registered dietician who understands FH.
Lifestyle management includes:
- Diets low in saturated and trans fats, low in cholesterol
- Regular exercise
- Weight control
- Not smoking
It is also important to manage all other risk factors for heart disease, including hypertension (high blood pressure), diabetes, and smoking. The Family Heart Foundation can connect you to other individuals with FH to see what works for them. We can help you maintain your health through our CASCADE FH® Patient Portal, which provides resources to track your heart health, medications, and more.